Crystal Structures and Cytotoxicity ofent-Kaurane-TypeDiterpenoids from TwoAspiliaSpecies
Guantai, Eric M.
Vincent, K. W. Wong
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A phytochemical investigation of the roots ofAspilia plurisetaled to the isolationofent-kaurane-type diterpenoids and additional phytochemicals (1–23).The structures ofthe isolated compounds were elucidated based on Nuclear Magnetic Resonance (NMR)spectroscopic and mass spectrometric analyses. The absolute configurations of seven of theent-kaurane-type diterpenoids (3–6,6b, 7and8) were determined by single crystal X-raydiffraction studies.Eleven of the compounds were also isolated from the roots and theaerial parts ofAspilia mossambicensis. The literature NMR assignments for compounds1and5were revised.In a cytotoxicity assay, 12α-methoxy-ent-kaur-9(11),16-dien-19-oic acid (1)(IC50= 27.3±1.9μM) and 9β-hydroxy-15α-angeloyloxy-ent-kaur-16-en-19-oic acid (3) (IC50=24.7±2.8μM) were the most cytotoxic against the hepatocellular carcinoma (Hep-G2) cell line,while 15α-angeloyloxy-16β,17-epoxy-ent-kauran-19-oic acid (5) (IC50= 30.7±1.7μM) was the mostcytotoxic against adenocarcinomic human alveolar basal epithelial (A549) cells.
CitationYaouba S, Valkonen A, Coghi P, Gao J, Guantai EM, Derese S, Wong VKW, Erdélyi Máté, Yenesew A. "Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species." Molecules. 2018;23(12):31-99.
University of Nairobi