Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei
Date
2016Author
Negera, Abdissa
Fangfang, Pan
Amra, Gruhonjic
Jürgen, Gräfenstein
Fitzpatrick, Paul A.
Göran, Landberg
Kari, Rissanen
Abiy, Yenesew
Máté, Erdély
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The phytochemical investigation of the CH2Cl2/MeOH (1:1) extract of the roots of Pentas parvifolia led to the isolation of three new naphthalenes, parvinaphthols A (1), B (2), and C (3), two known anthraquinones, and five known naphthalene derivatives. Similar investigation of the roots of Pentas bussei afforded a new polycyclic naphthalene, busseihydroquinone E (4), a new 2,2′-binaphthralenyl-1,1′-dione, busseihydroquinone F (5), and five known naphthalenes. All purified metabolites were characterized by NMR and MS data analyses, whereas the absolute configurations of 3 and 4 were determined by single-crystal X-ray diffraction studies. The E-geometry of compound 5 was supported by DFT-based chemical shift calculations. Compounds 2–4 showed marginal cytotoxicity against the MDA-MB-231 human triple-negative breast cancer cell line with IC50 values ranging from 62.3 to 129.6 μM.
URI
https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.6b00178http://erepository.uonbi.ac.ke/handle/11295/107096
Citation
Abdissa, Negera, et al. "Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei." Journal of natural products 79.9 (2016): 2181-2187.Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
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