Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei
Fitzpatrick, Paul A.
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The phytochemical investigation of the CH2Cl2/MeOH (1:1) extract of the roots of Pentas parvifolia led to the isolation of three new naphthalenes, parvinaphthols A (1), B (2), and C (3), two known anthraquinones, and five known naphthalene derivatives. Similar investigation of the roots of Pentas bussei afforded a new polycyclic naphthalene, busseihydroquinone E (4), a new 2,2′-binaphthralenyl-1,1′-dione, busseihydroquinone F (5), and five known naphthalenes. All purified metabolites were characterized by NMR and MS data analyses, whereas the absolute configurations of 3 and 4 were determined by single-crystal X-ray diffraction studies. The E-geometry of compound 5 was supported by DFT-based chemical shift calculations. Compounds 2–4 showed marginal cytotoxicity against the MDA-MB-231 human triple-negative breast cancer cell line with IC50 values ranging from 62.3 to 129.6 μM.
CitationAbdissa, Negera, et al. "Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei." Journal of natural products 79.9 (2016): 2181-2187.
University of Nairobi
RightsAttribution-NonCommercial-NoDerivs 3.0 United States
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