| dc.contributor.author | Sinei, Kipruto A. | |
| dc.contributor.author | Redfern, P.H. | |
| dc.date.accessioned | 2013-02-22T13:02:56Z | |
| dc.date.issued | 1994 | |
| dc.identifier.citation | Chronobiology International Vol. II, No. I, pp. 27-34 | en |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10784 | |
| dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/8013048 | |
| dc.description.abstract | Tryptophan hydroxylase activity has been measured in synaptosomal preparations from rat brain. A significant circadian variation in enzyme activity was apparent in corpus striatum, (p < 0.00 I), brainstem and cortex (p < 0.0 I). A single dose of clomipramine or mianserin (20 mg/kg) had no effect on brainstem enzyme activity measured at mid-light or mid-dark. Chronic administration (7.5 rng/kg i.p. twice daily for 2 weeks) of either clomipramine or mianserin significantly increased enzyme activity. There was no significant difference between the drug effects measured at mid-light or mid-dark. | en |
| dc.language.iso | en | en |
| dc.subject | Tryptophan | en |
| dc.subject | 5-hydroxylase | en |
| dc.subject | Clomipramine | en |
| dc.subject | Mianserin | en |
| dc.subject | Circadian | en |
| dc.subject | Serotonin | en |
| dc.title | Effects of the antidepressant drugs clomipramine and mianserin on tryptophan hydroxylase activity in the rat brain, measured at two points in the light/dark cycle | en |
| dc.type | Article | en |
| local.publisher | Pharmacology Group, School of Pharmacy and Pharmacology, University of Bath, Bath, England | en |
