dc.contributor.author | Kaminsky, R. | |
dc.contributor.author | Chuma, F. | |
dc.contributor.author | Wasike, R.P.N. | |
dc.date.accessioned | 2013-02-25T09:09:45Z | |
dc.date.issued | 1994 | |
dc.identifier.citation | Veterinary Parasitology 52 (1994) 235-242 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/11115 | |
dc.description.abstract | Trypanosoma congolense bloodstream forms were propagated in vitro axenically in a
simplified cultivation medium at 34 ° C. Viability of a drug-sensitive and a drug-resistant
clone were examined for 10 days following exposure to 0.1, 1.0 and 10.0/~g ml- 1 of diminazene
aceturate and 0.1, 1.0 and 10.0 ng ml-~ of isometamidium chloride for various
time intervals. Drug-sensitive T. congolense were irreversibly damaged after incubation
with 10/~g ml- ~ or 1 #g ml- 1 diminazene aceturate for 30 min or 2 h, respectively, while
drug-resistant trypanosomes were not affected. Exposure to 10 ng ml-~ isometamidium
chloride eliminated drug-sensitive trypanosomes after 24 h and drug-resistant trypanosomes
after 96 h. The data obtained on in vitro time-dose responses of T. congolense were
related to pharmacokinetic data of diminazene and isometamidium in cattle plasma. | en |
dc.language.iso | en | en |
dc.subject | Trypanosoma congolense | en |
dc.subject | Diminazene | en |
dc.subject | Isometamidium | en |
dc.subject | Control methods-Protozoa | en |
dc.title | Time-dose response of Trypanosoma congolense bloodstream forms to diminazene and isometamidium | en |
dc.type | Article | en |
local.publisher | International Laboratory for Research on Animal Diseases (ILRAD) | en |