Acute cytomegalovirus infection in Kenyan HIV-infected infants
Date
2009Author
Slyker, Jennifer A
Lohman-Payne, Barbara L
John-Stewart, Grace C
Maleche-Obimbo, Elizabeth
Emery, Sandra
Richardson, Barbra
Dong, Tao
Iversena, Astrid K N
Mbori-Ngacha, DA
Overbaugh, Julie
Rowland-Jones, Sarah L
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Objective: Cytomegalovirus (CMV) coinfection may influence HIV-1 disease progression
during infancy. Our aim was to describe the incidence of CMV infection
and the kinetics of viral replication in Kenyan HIV-infected and HIV-exposed uninfected
infants.
Methods: HIV-1 and CMV plasma viral loads were serially measured in 20 HIVexposed
uninfected and 44 HIV-infected infants born to HIV-infected mothers.
HIV-infected children were studied for the first 2 years of life, and HIV-exposed
uninfected infants were studied for 1 year.
Results: CMVDNAwas detected frequently during the firstmonths of life; by 3months of
age,CMVDNAwasdetectedin90%ofHIV-exposeduninfectedinfantsand93%of infants
whohadacquiredHIV-1inutero.CMVviral loadswerehighest inthe1–3monthsfollowing
the first detection of virus and declined rapidly thereafter. CMV peak viral loads were
significantlyhigher in theHIV-infectedinfantscomparedwith theHIV-exposeduninfected
infants (mean3.2versus2.7 log10CMVDNAcopies/ml, respectively,P¼0.03).Thedetection
of CMV DNA persisted to 7–9 months post-CMV infection in both the HIV-exposed
uninfected (8/17, 47%) and HIV-infected (13/18, 72%, P¼0.2) children. Among HIVinfected
children, CMV DNA was detected in three of the seven (43%) surviving infants
tested between 19 and 21 months post-CMV infection. Finally, a strong correlation was
found between peak CMV and HIV-1 viral loads (r¼0.40, P¼0.008).
Conclusion: Acute CMV coinfection is common in HIV-infected Kenyan infants. HIV-1
infection was associated with impaired containment of CMV replication.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/11141http://www.ncbi.nlm.nih.gov/pubmed/19617812
Citation
AIDSPublisher
Department of Paediatrics, University of Nairobi, Nairobi, Kenya
Collections
- Faculty of Health Sciences (FHS) [10377]