Infants with late breast milk acquisition of HIV-1 generate interferon-gamma responses more rapidly than infants with early peripartum acquisition
Date
2009Author
Lohman-Payne, B
Slyker, J. A.
Richardson, BA
Farquhar, C
Majiwa, M.
Maleche-Obimbo, E
Mbori-Ngacha, DA
Overbaugh, J
Rowland-Jones, S
John-Stewart†, G
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Infants infected with HIV-1 after the first month of life have a lower viral
set-point and slower disease progression than infants infected before 1
month. We investigated the kinetics of HIV-1-specific CD8+ T lymphocyte
secretion of interferon (IFN)-g in infants infected before 1 month of life
compared with those infected between months 1 and 12 (late infection).
HIV-1 infection was assessed at birth and at months 1, 3, 6, 9 and 12 and
timing of infection was determined by HIV-1 gag DNA from dried blood
spots and verified by plasma HIV-1 RNA levels. HIV-1 peptide-specific
IFN-g responses were measured by enzyme-linked immunospot at months 1,
3, 6, 9 and 12. Timing of development of IFN-g responses was compared
using the log–rank test and Kaplan–Meier survival curves. Infants infected
late developed HIV-1-specific CD8+ T cell responses 2·8 months sooner than
infants infected peripartum: 2·3 versus 5·1 months after HIV-1 infection
(n = 52, P = 0·04). Late-infected infants had more focused epitope recognition
than early-infected infants (median 1 versus 2 peptides, P = 0·03);
however, there were no differences in the strength of IFN-g responses. In
infants infected with HIV-1 after the first month of life, emergence of HIV-
1-specific CD8+ IFN-g responses is coincident with the decline in viral load,
nearly identical to what is observed in adults and more rapid than in earlyinfected
infants.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/11285http://www.ncbi.nlm.nih.gov/pubmed/19438605
Citation
British Society for Immunology, Clinical and Experimental ImmunologyPublisher
Department of Paediatrics, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10378]