Risk factors for neonatal conjunctivitis in babies of HIV-1 infected mothers
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Date
2009Author
Gichuhi, Stephen
Bosire, Rose
Mbori-Ngacha, DA
Gichuhi, Christine
Wamalwa, Dalton
Maleche-Obimbo, Elizabeth
Farquhar, Carey
Wariua, Grace
Otieno, Phelgona
John-Stewart, Grace C.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Purpose—To determine the prevalence and correlates of neonatal conjunctivitis in infants born
to human immunodeficiency virus type 1 (HIV-1) infected mothers.
Methods—This was a nested case-control study within a perinatal HIV-1 cohort. HIV-1
seropositive mothers were enrolled during pregnancy and mother-infant pairs followed after
delivery with assessment for neonatal conjunctivitis at 48 hours and up to 4 weeks after birth.
Genital infections (chlamydia, gonorrhea, syphilis, trichomonas, bacterial vaginosis, and candida)
were screened for at 32 weeks gestation. Mothers received treatment for genital infections
diagnosed during pregnancy and short-course zidovudine. Newborns did not receive ocular
prophylaxis at hospital deliveries. Multivariate logistic regression models were used to determine
cofactors for neonatal conjunctivitis overall and stratified for infant HIV-1 status.
Results—Four hundred and fifty-two infants were assessed and 101 (22.3%) had neonatal
conjunctivitis during the first month postpartum. In multivariate analyses using odds ratios (OR)
and confidence intervals (CI), neonatal conjunctivitis was associated with neonatal sepsis
(adjusted OR 21.95, 95% CI 1.76, 274.61), birth before arrival to hospital (adjusted OR 13.91,
95% CI 1.39, 138.78) and birth weight (median 3.4 versus 3.3 kilograms, p=0.016, OR 1.79, 95%
CI 1.01, 3.15). Infant HIV-1 infection was not associated with conjunctivitis.
Conclusions—Despite detection and treatment of genital infections during pregnancy, neonatal
conjunctivitis was frequently diagnosed in infants born to HIV-1 infected mothers suggesting a
need for increased vigilance and prophylaxis for conjunctivitis in these infants. Neonatal sepsis,
birth before arrival to hospital, and higher birthweight are factors that may predict higher risk of
neonatal conjunctivitis in this population.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/11543http://www.ncbi.nlm.nih.gov/pubmed/19995198
Citation
Ophthalmic EpidemiolPublisher
Pharmacology and Therapeutics, University of Nairobi, Kenya
Collections
- Faculty of Health Sciences (FHS) [10387]