dc.contributor.author | Jonnalagadda, Sasi | |
dc.contributor.author | Payne, Barbara Lohman | |
dc.contributor.author | Brown, Elizabeth | |
dc.contributor.author | Wamalwa, Dalton | |
dc.contributor.author | Obimbo, Elizabeth Maleche | |
dc.contributor.author | Majiwa, Maxwel | |
dc.contributor.author | Farquhar, Carey | |
dc.contributor.author | Otieno, Phelgona | |
dc.contributor.author | Mbori-Ngacha, DA | |
dc.contributor.author | John-Stewart, Grace | |
dc.date.accessioned | 2013-02-26T14:15:11Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | J Infect Dis. | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/11852 | |
dc.description.abstract | Background—We evaluated the prognostic utility of interferon-gamma release assays (IGRAs)
for active tuberculosis (TB) and mortality in Kenyan HIV-1 infected women and their infants.
Methods—Prevalence and correlates of Mycobacterium tuberculosis-specific T-SPOT.TB IGRA
positivity were determined during pregnancy in a historical cohort of HIV-1 infected women.
Hazard ratios, adjusted for baseline maternal CD4 count (aHRCD4) were calculated for
associations between IGRA positivity and risk of active TB and mortality over 2-year postpartum
follow-up in women and their infants.
Results—Of 333 women tested, 52 (15.6%) had indeterminate IGRAs. Of the remaining 281
women, 120 (42.7%) had positive IGRAs, which were associated with a 4.5-fold increased risk of
active TB [aHRCD4: 4.5; 95% confidence interval (CI): 1.1–18.0; p=0.03]. Among
immunosuppresed women (CD4<250 cell/mm3), positive IGRAs were associated with increased
risk of maternal mortality (aHRCD4: 3.5; 95% CI: 1.02–12.1; p=0.045), maternal active TB or
mortality (aHRCD4: 5.2; 95% CI: 1.7–15.6; p=0.004) and infant active TB or mortality, overall | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | 15; 202(12): 1826–1835; | |
dc.subject | Latent tuberculosis infection; HIV-1; women; infants; T-SPOT.TB; IGRA | en |
dc.title | Latent TB detection by interferon gamma release assay (IGRA) in pregnancy predicts active TB and mortality in HIV-1 infected women and their children | en |
dc.type | Article | en |
local.publisher | 6Department of Paediatrics, University of Nairobi, Nairobi, Kenya | en |