Conversion of vernonia galamensis oil to pyridinylvernolamides and their antimicrobial activities
Date
2006Author
Mbugua, M N
Yusuf, A O
Gitu, P M
Bhat, B M
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Vernonia oil obtained by Soxhlet extraction from the seeds of Vernonia
galamensis ssp. nairobensis was reacted with 2-aminopyridine, 2-(aminomethyl)pyridine and
2-(aminoethyl)pyridine using a 1:3 mole ratio of vernonia oil to amine at varied temperatures
to give the corresponding vernolamides. The expected vernolamide from the reaction of 2aminopyridine
and the oil was not formed. N-(2-pyridinylmethyl)vernolamide and N-(2pyridinylethyl)vernolamide
.exhibited antibacterial activity that was shown to be higher
against gram-positive (Bacillus subtiIis) than gram-negative (Escherichia colt) bacteria. The
vernolamides did not show any antifungal activity.
Citation
Bull.Chem.Soc. Ethiop.2007, 21(1), 103-110Publisher
Chemical Society of Ethiopia Chemistry
Subject
Vernonia galamensis2-Aminopyridine
N-(2-pyridinylmethyl)vernolamide
N-(2-pyridinylethyl)vernolamide
Antimicrobial activity