dc.contributor.author | Shina, L Y Y | |
dc.contributor.author | Ngugi, Elizabeth N | |
dc.contributor.author | Kimani, J | |
dc.contributor.author | Rebbapragada, A | |
dc.contributor.author | Sheung, A | |
dc.contributor.author | Kaul, R | |
dc.contributor.author | Gray-Owen, S | |
dc.contributor.author | Moses, S | |
dc.contributor.author | Dobson-Belaire, W | |
dc.contributor.author | MacDonald, K S | |
dc.date.accessioned | 2013-02-26T15:59:47Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | AIDS 2008, Vol 22 No 14 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/11894 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/18753933 | |
dc.description.abstract | Background: The host immune response against mucosally acquired pathogens may be
influenced by the mucosal immune milieu during acquisition. As Neisseria gonorrhoeae
can impair dendritic cell and T-cell immune function, we hypothesized that coinfection
during HIV acquisition would impair subsequent systemic T-cell responses.
Methods: Monthly screening for sexually transmitted infections was performed in high
risk, HIV seronegative Kenyan female sex workers as part of an HIV prevention trial.
Early HIV-specific CD8 T-cell responses and subsequent HIV viral load set point were
assayed in participants acquiring HIV, and were correlated with the presence of prior
genital infections during HIV acquisition.
Results: Thirty-five participants acquired HIV during follow-up, and 16 out of 35 (46%)
had a classical sexually transmitted infection at the time of acquisition. N. gonorrhoeae
coinfection was present during HIV acquisition in 6 out of 35 (17%), and was associated
with an increased breadth and magnitude of systemic HIV-specific CD8 T-cell
responses, using both interferon-gammag and MIP-1 beta as an output. No other
genital infections were associated with differences in HIV-specific CD8 T-cell response,
and neither N. gonorrhoeae nor other genital infections were associated with differences
in HIV plasma viral load at set point.
Conclusion: Unexpectedly, genital N. gonorrhoeae infection during heterosexual HIV
acquisition was associated with substantially enhanced HIV-specific CD8 T-cell
responses, although not with differences in HIV viral load set point. This may have
implications for the development of mucosal HIV vaccines and adjuvants. | en |
dc.language.iso | en | en |
dc.subject | CD8 T cells | en |
dc.subject | female sex workers | en |
dc.subject | gonorrhea | en |
dc.subject | HIV | en |
dc.subject | mucosal immunology | en |
dc.title | Mucosal Neisseria gonorrhoeae coinfection during HIV acquisition is associated with enhanced systemic HIV-specific CD8 T-cell responses | en |
dc.type | Article | en |
local.publisher | Department of Community Health, University of Nairobi, Nairobi, Kenya | en |