Impairment of CD1d-restricted Natural Killer T cells in chronic HIV-1 clade C infection
dc.contributor.author | Mureithi, Marianne W. | |
dc.contributor.author | Cohen, Kristen | |
dc.contributor.author | Moodley, Ramona | |
dc.contributor.author | Poole, Danielle | |
dc.contributor.author | Mncube, Zenele | |
dc.contributor.author | Kasmar, Anne | |
dc.contributor.author | Moody, D. Branch | |
dc.contributor.author | Goulder, Philip J.R. | |
dc.contributor.author | Walker, Bruce D. | |
dc.contributor.author | Altfeld, Marcus | |
dc.contributor.author | Ndung’u, Thumbi | |
dc.date.accessioned | 2013-02-27T14:23:39Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | AIDS Res Hum Retroviruses. 2010 Oct 14. | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/12144 | |
dc.description.abstract | Recent studies suggest that Natural Killer T (NKT) cells play a role in early antiviral pathogenesis and have been shown to play a critical role in protective immunity to many infections observed in immunocompromised individuals, including mycobacterium tuberculosis. NKT cells are rapidly depleted in chronic human immunodeficiency virus type 1 (HIV-1) clade B infection and no known studies to date have yet assessed the impact of HIV-1 infection on NKT cell number and function in sub-Saharan Africa where HIV- 1 clade C is the predominant subtype. We aimed to characterize the phenotypic and functional characteristics of NKT cells in HIV-1 clade C-infected Africans at different stages of HIV-1 disease. We observed a significant decline of NKT cell numbers in advanced HIV-1 disease as well as activation and functional impairment of NKT cells in individuals with low CD4 T cell counts. The loss of NKT cells was largely driven by a reduction in the CD4+ and CD4negCD8neg NKT cell subsets in advanced disease. Overall, we demonstrated significant impairment of the NKT cell compartment in progressive HIV-1 clade C disease that might play an important role in the modulation of immune function in HIV-1 infection | en |
dc.language.iso | en | en |
dc.title | Impairment of CD1d-restricted Natural Killer T cells in chronic HIV-1 clade C infection | en |
dc.type | Article | en |
Files in this item
This item appears in the following Collection(s)
-
Faculty of Health Sciences (FHS) [10378]