Browsing BioMedical Journal Articles by Author "John-Stewart, Grace"
Now showing items 1-6 of 6
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Evaluation of a single round polymerase chain reaction assay using dried blood spots for diagnosis of HIV-1 infection in infants in an African setting
Chohan, Bhavna H; Emery, Sandra; Wamalwa, Dalton; John-Stewart, Grace; Majiwa, Maxwel; Ng'ayo, Musa; Froggett, Steve; Overbaugh, Julie (2011-02-18)Abstract Background The aim of this study was to develop an economical 'in-house' single round polymerase chain reaction (PCR) assay using filter paper-dried blood spots (FP-DBS) for early infant HIV-1 diagnosis ... -
Medication diaries do not improve outcomes with highly active antiretroviral therapy in Kenyan children: a randomized clinical trial
Wamalwa, Dalton C; Farquhar, Carey; Obimbo, Elizabeth M; Selig, Sara; Mbori-Ngacha, DA; Richardson, Barbra A; Overbaugh, Julie; Egondi, Thaddeus; Inwani, Irene; John-Stewart, Grace (2009-06-24)Abstract Background As highly active antiretroviral therapy (HAART) becomes increasingly available to African children, it ... -
Phenotypic characterization of HIV-specific CD8 T cells during acute infant HIV infection
Slyker, Jennifer; Dong, Tao; John-Stewart, Grace; Lohman-Payne, Barbara; Reilly, Marie; Atzberger, Ann; Taylor, Stephen; Maleche-Obimbo, Elizabeth; Mbori-Ngacha, DA; Rowland-Jones, Sarah (2009-07-22)Although CD8(+) T cells play an important role in the containment of adult HIV-1 replication, their role in infant HIV-1 infection is not as well understood. Impaired HIV-specific CD8(+) T cell responses may underlie the ... -
Predictors of mortality in HIV-1 infected children on antiretroviral therapy in Kenya: a prospective cohort
Wamalwa, Dalton C; Obimbo, Elizabeth M; Farquhar, Carey; Richardson, Barbra A; Mbori-Ngacha, DA; Inwani, Irene; Benki-Nugent, Sara; John-Stewart, Grace (2010-05-18)Abstract Background Among children, early mortality following highly active antiretroviral therapy (HAART) remains high. It ... -
The role of G Protein Gene GNB3 C825T Polymorphism in HIV-1 acquisition, progression and immune activation
Juno, Jennifer; Tuff, Jeffrey; Choi, Robert; Card, Catherine; Kimani, Joshua; Wachihi, Charles; Koesters-Kiazyk, Sandra; Ball, T Blake; Farquhar, Carey; Plummer, Francis A; John-Stewart, Grace; Luo, Ma; Fowke, Keith R (2012-01-03)Abstract Background The GNB3 C825T polymorphism is associated with increased G protein-mediated signal transduction, SDF-1α-mediated lymphocyte chemotaxis, accelerated HIV-1 progression, and altered responses to ... -
Uptake of prevention of mother to child transmission interventions in Kenya: health systems are more influential than stigma
Kinuthia, J; Kiarie, James N; Farquhar, Carey; Richardson, Barbra A; Nduati, RW; Mbori-Ngacha, DA; John-Stewart, Grace (2011-12-28)Abstract Background We set out to determine the relative roles of stigma versus health systems in non-uptake of prevention of mother to child transmission (PMTCT) of HIV-1 interventions: we conducted cross-sectional ...