dc.contributor.author | Kiulia, NM | |
dc.contributor.author | Nyaundi, JK | |
dc.contributor.author | Peenze, I | |
dc.contributor.author | Nyachieo, A | |
dc.contributor.author | Musoke, RN | |
dc.contributor.author | Steele, AD | |
dc.date.accessioned | 2013-03-26T09:45:18Z | |
dc.date.available | 2013-03-26T09:45:18Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | J Trop Pediatr 2009 Oct;55(5):318-23 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/15115 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/19276145 | |
dc.description.abstract | Human rotaviruses have emerged as a leading cause of acute diarrhea in children <5 years of age worldwide. Although there are previous reports relating to various aspects of rotaviruses, there is limited data on the involvement of rotavirus infection in HIV-infected children. We therefore evaluated the importance of rotavirus infections in HIV-related diarrhea in Kenyan children. Fecal samples were collected from a total of 207 children during the period February 1999 to June 2000 and screened for HRV antigen by enzyme-linked immunosorbent assay (ELISA). Positive samples were analyzed by VP6 subgroup specificity assay, by polyacrylamide gel electrophoresis (PAGE) and reverse transcriptase/polymerase chain reaction (RT-PCR). Fourteen percent (29/207) of the samples were positive. HIV-seropositive children with diarrhea were more likely than their counterparts without diarrhea to have rotaviruses [23.3% (10/43) versus 2.9% (2/70); p = 0.0001]. Rotavirus strain G3P[6] was predominant. These results indicate that rotavirus is an important viral etiological agent causing diarrhea in HIV-seropositive children | en |
dc.language.iso | en | en |
dc.title | Rotavirus infections among HIV-infected children in Nairobi, Kenya | en |
dc.type | Article | en |
local.publisher | Department of Paediatrics | en |