Establishing and sustaining a healthy vaginal environment: analysis of data from a randomized trial of periodic presumptive treatment for vaginal infections
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Date
2011Author
Balkus, JE
Richardson, BA
Mandaliya, K
Kiarie, J
Jaoko Walter G.
Ndinya-Achola JO.
Marrazzo, J
Farquhar, C
McClelland, RS
Advisor
Type
ArticleLanguage
enMetadata
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Data from a randomized trial of oral periodic presumptive treatment (PPT) to reduce vaginal infections were analyzed to assess the effect of the intervention on a healthy vaginal environment (normal flora confirmed by Gram stain with no candidiasis or trichomoniasis). The incidence of a healthy vaginal environment was 608 cases per 100 person-years in the intervention arm and 454 cases per 100 person-years in the placebo arm (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.17–1.58). Sustained vaginal health (healthy vaginal environment for ≥3 consecutive visits) was also more frequent in the intervention arm (HR, 1.69; 95% CI, 1.23–2.33). PPT is effective at establishing and sustaining a healthy vaginal environment.
URI
http://www.ncbi.nlm.nih.gov/pubmed/21673045http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/15244
Local Identifier
doi: 10.1093/infdis/jir241Citation
J Infect Dis. 2011 Jul 15;204(2):323-6Publisher
Department of Epidemiology, University of Washington, Seattle, WA 98104, USA Department of Medical Microbiology, University of Nairobi de
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- Faculty of Health Sciences (FHS) [10377]