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dc.date.accessioned2020-06-29T08:07:49Z
dc.date.available2020-06-29T08:07:49Z
dc.date.issued2015-12
dc.identifier.citationBMC Complement Altern Med. 2015 Dec 30;15(1):453.en_US
dc.identifier.urihttp://download.springer.com/static/pdf/229/art%253A10.1186%252Fs12906-015-0978-8.pdf?originUrl=http%3A%2F%2Fbmccomplementalternmed.biomedcentral.com%2Farticle%2F10.1186%2Fs12906-015-0978-8&token2=exp=1451906135~acl=%2Fstatic%2Fpdf%2F229%2Fart%25253A10.1186%25252Fs12906-015-0978-8.pdf*~hmac=740df5eb7143c19ba65caad9075ab42f4967b044919eba9328917af04e281087
dc.identifier.urihttp://erepository.uonbi.ac.ke/handle/11295/152884
dc.description.abstractBackground: In the present study, the methanol extracts from the leaves, as well as compounds namely sigmoidin I (1), atalantoflavone (2), bidwillon A (3), neocyclomorusin (4), 6α-hydroxyphaseollidin (5) and neobavaisoflavone (6) (from the bark extract) were tested for their activities against a panel of Gram-negative bacteria including multi-drug resistant (MDR) phenotypes. Methods: Broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) of the extracts as well as compounds 1–6. Results: The MIC results indicated that the crude extracts from the leaves and bark of this plant were able to inhibit the growth of 96.3 % of the 27 tested bacteria. Compounds 2–6 displayed selective activities, their inhibitory effects being obtained on 8.3 %, 41.7 %, 58.3 %, 58.3 % and 66.7 % of tested bacteria respectively for 2, 3, 5, 6 and 4. The lowest MIC value of 8 μg/mL was obtained with 6 against Escherichia coli ATCC8739, Enterobacter cloacae ECCI69, Klebsiella pneumoniae KP55, Providencia stuartii NAE16 and Pseudomonas aeruginosa PA01. Conclusion: The present study demonstrates that Erythrina sigmoidea is a potential source of antibacterial drugs to fight against MDR bacteria. Neobavaisoflavone (6) is the main antibacterial consituents of the bark crude extracten_US
dc.language.isoenen_US
dc.publisherUniversity of Nairobien_US
dc.subjectAntibacterial, Erythrina sigmoidea, Compounds, Multidrug resistance, Neobavaisoflavoneen_US
dc.titleAntibacterial activities of the methanol extracts and compounds from Erythrina sigmoidea against Gram-negative multi-drug resistant phenotypes.en_US
dc.typeArticleen_US


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