dc.contributor.author | Masyuko, Sarah J. | |
dc.contributor.author | Page, Stephanie T. | |
dc.contributor.author | Kinuthia, John | |
dc.contributor.author | Osoti, Alfred O. | |
dc.contributor.author | Polyak, Stephen J. | |
dc.contributor.author | C. Otieno, Fredrick | |
dc.contributor.author | Kibachio, Joseph M. | |
dc.contributor.author | Mogaka, Jerusha N. | |
dc.contributor.author | Temu, Tecla M. | |
dc.contributor.author | Zifodya, Jerry S. | |
dc.contributor.author | Otedo, Amos | |
dc.contributor.author | Damelie, Nakanjako | |
dc.contributor.author | Hughes, James P. | |
dc.contributor.author | Farquhar, Carey | |
dc.date.accessioned | 2020-11-20T07:00:39Z | |
dc.date.available | 2020-11-20T07:00:39Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Medicine (Baltimore). 2020 Jul 2; 99(27): e20845. | en_US |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337552/ | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/153453 | |
dc.description.abstract | To determine the prevalence and correlates of metabolic syndrome (MetS) and compare 10-year cardiovascular disease (CVD) risk among Kenyan adults with and without HIV infection.
We conducted a cross-sectional study among adults ≥30 years of age with and without HIV infection seeking care at Kisumu County Hospital. Participants completed a health questionnaire and vital signs, anthropomorphic measurements, and fasting blood were obtained. MetS was defined using 2009 Consensus Criteria and 10-year Atherosclerotic CVD (ASCVD) risk score was calculated. Chi-square, independent t tests, Wilcoxon ranksum test and multivariable logistic regression were used to determine differences and associations between HIV and MetS, CVD risk factors and ASCVD risk score.
A total of 300 people living with HIV (PLWHIV) and 298 HIV-negative participants with median age 44 years enrolled, 50% of whom were female. The prevalence of MetS was 8.9% overall, but lower among PLWHIV than HIV-negative participants (6.3% vs 11.6%, respectively; P = .001). The most prevalent MetS components were elevated blood pressure, decreased high density lipoprotein, and abdominal obesity. Adjusting for covariates, PLWHIV were 66% less likely to have MetS compared to HIV-negative participants (adjusted odds ratio [aOR] 0.34; 95% confidence interval [95%CI] 0.18, 0.65; P = .005). Median ASCVD risk score was also lower among PLWHIV compared to HIV-negative participants (1.7% vs 3.0%, P = .002).
MetS was more common among HIV-negative than HIV-positive adults, and HIV-negative adults were at greater risk for CVD compared to PLWHIV. These data support integration of routine CVD screening and management into health programs in resource-limited settings, regardless of HIV status. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | cardiovascular risk score, HIV, Kenya, metabolic syndrome Go to: 1. Introduction | en_US |
dc.title | Metabolic syndrome and 10-year cardiovascular risk among HIV-positive and HIV-negative adults | en_US |
dc.type | Article | en_US |