dc.contributor.author | Odera, Susan | |
dc.contributor.author | Mureithi, Marianne | |
dc.contributor.author | Aballa, Andrew | |
dc.contributor.author | Onyango, Noel | |
dc.contributor.author | Anzala, Omu | |
dc.contributor.author | Oyugi, Julius | |
dc.date.accessioned | 2020-12-17T07:14:15Z | |
dc.date.available | 2020-12-17T07:14:15Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | 10.11604/pamj.2020.37.87.21102. eCollection 2020. | en_US |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/33244350/ | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/153544 | |
dc.description.abstract | Introduction: Household Contacts (HHCs) of Pulmonary Tuberculosis (PTB) patients have a higher risk of latent tuberculosis infection (LTBI). However, its prevalence and risk factors among adults living with PTB patients are poorly documented in Kenya.
Objective: to determine the prevalence and risk factors for LTBI among adult HHCs of PTB patients in Kenya.
Methods: this was an analytical cross-sectional study of HHCs of PTB patients in Nairobi, Kenya. Socio-demographic data was captured on questionnaires and blood samples drawn for Interferon gamma (IFN-γ) quantification. Univariate and multivariate analyses using the Statistical Package for Social Scientists (SPSS) was used to determine the prevalence of LTBI and risk factors at 95% Confidence Interval (CI).
Results: a total of 166 PTB patients yielded 175 HHCs of whom 29.7% (52/125) were males and 70.3% (123/125) were females. A majority of HHCs [65.7% (115/175)] lived in a single-room house with the patient and [37.7% (66/175)] were in the age group 30-39-years. The overall prevalence of LTBI was 55.7%, peaking among spouses of the patients [70.0% (14/20) and the 30-39 year age group [63.5% (42/66)]. Potential risk factors for LTBI included cohabiting with a PTB patient for 8 to 12 weeks [OR = 3.6 (0.70-18.5), p = 0.107], being a spouse of the patient [OR = 2.0 (0.72-5.47), p = 0.173] and sharing a single room with the patient [OR = 1.58 (0.84 - 2.97), p = 0.158].
Conclusion: the high prevalence of LTBI among adult HHCs of PTB patients in this population demonstrates the need for targeted contact-screening programs in high TB transmission settings. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Kenya; Latent TB infection; TB household contacts; prevalence; risk factors. | en_US |
dc.title | Latent tuberculosis among household contacts of pulmonary tuberculosis cases in Nairobi, Kenya | en_US |
dc.type | Article | en_US |