dc.contributor.author | Kiuri, J N | |
dc.contributor.author | Maru, S. M. | |
dc.contributor.author | Ndwigah, S. N | |
dc.date.accessioned | 2021-01-13T07:21:37Z | |
dc.date.available | 2021-01-13T07:21:37Z | |
dc.date.issued | 2020-09-03 | |
dc.identifier.citation | Kiuri, J. N., Maru, S. M., & Ndwigah, S. N. (2020). Product Evaluation of Carbamazepine 200mg Controlled Release Tablets using an in vitro-in vivo Correlation Simulation Model. East and Central African Journal of Pharmaceutical Sciences, 23(2), 60-66. | en_US |
dc.identifier.uri | https://www.ajol.info/index.php/ecajps/article/view/200123 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/153587 | |
dc.description.abstract | Evaluation of the dissolution characteristics of drugs and their bioavailability
can be conducted using an in vitro-in vivo correlation model. This can help in
assessing the products available in the market for quality. Random testing in
post-marketing surveillance would gauge the quality of the drug products. This
study involved evaluation of three batches of controlled-release carbamazepine,
Tegretol 200mg CR®
tablets through dissolution tests from which a dissolution
profile and blood concentration-time profile were derived. The in vitro-in vivo
correlation simulation model was used to determine the Area Under Curve and
Maximum Plasma Concentration and demonstrate bioequivalence of the
product batches. The three batches exhibited similarity upon statistical analysis.
The results also correspond to the values obtained in literature from
bioequivalence studies. In vitro-in vivo correlation can thus be a useful
instrument in pharmacovigilance for marketed drug products. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | East Cent. Afr. J. Pharm. Sci | en_US |
dc.subject | IVIVC, carbamazepine, bioavailability, pharmacokinetic parameters, dissolution | en_US |
dc.title | Product evaluation of carbamazepine 200mg controlled release tablets using an in vitro-in vivo correlation simulation mode | en_US |
dc.type | Article | en_US |