Management of lupus nephritis at the Kenyatta National Hospital

View/ Open
Date
1990Author
Otieno, LS
McLigeyo, SO
Kayima, JK
Sitati, S
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
In 7 years (1981-1988) at the Kenyatta National Hospital (KNH), Nairobi the diagnosis of systemic lupus erythematosus (SLE) was made in 67 patients. In 23 of these patients lupus nephritis complicated the SLE. Lupus nephritis was diagnosed through renal biopsy, haematuria and proteinuria in urine with positive lupus erythematosus (LE) cell phenomenon. The histology found in these patients included 5 patients with minimal lesion, 7 patients with membranous, 3 with focal, 4 with diffuse, 3 with crescenteric and one with membranoproliferative glomerulonephritis. While patients with minimal, membranous and focal nephritis had general good outlook on low dose maintenance or intermittent high dose steroid therapy the others with diffuse, crescenteric and membranoproliferative nephritis had poor prognosis. Patients with diffuse proliferative, membranoproliferative and crescenteric nephritis tended to have septicaemia, pulmonary oedema, fluid overload and chronic renal failure with poor prognosis. These patients responded poorly to oral and parenteral steroid therapy whether high or low dose
URI
http://www.ncbi.nlm.nih.gov/pubmed/2279466http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/15479
Citation
East Afr Med J. 1990 Jun;67(6):387-95Publisher
Department of Medicine and Pathology, College of Health Sciences, University of Nairobi,
Collections
- Faculty of Health Sciences (FHS) [10214]