dc.contributor.author | Said, Nusrat A | |
dc.contributor.author | Kamenwa, Rose W | |
dc.contributor.author | Limbe, Mary S | |
dc.contributor.author | Okumu, Mitchel O | |
dc.contributor.author | Macharia, William M | |
dc.date.accessioned | 2021-08-11T09:42:55Z | |
dc.date.available | 2021-08-11T09:42:55Z | |
dc.date.issued | 2021-05 | |
dc.identifier.citation | Said NA, Kamenwa RW, Limbe MS, Okumu MO, Macharia WM. Prevalence of vitamin D deficiency in exclusively breastfed infants at a tertiary healthcare facility in Nairobi, Kenya. Arch Endocrinol Metab. 2021 May 18;64(6):726-734. doi: 10.20945/2359-3997000000281. PMID: 34033282. | en_US |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/34033282/ | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/155138 | |
dc.description.abstract | Objective: To determine the prevalence of vitamin D deficiency (VDD) in exclusively breastfed infants at the Aga Khan University Hospital Nairobi, Kenya (AKUHN). The relationships between 25-hydroxyvitamin D; 25OHD, parathyroid hormone (PTH), maternal vitamin D supplementation, and sunlight exposure were also determined.
Methods: Blood from 98 infants was assayed for 25OHD, calcium, phosphate, and PTH. Socio-demographic and clinical characteristics were analyzed using descriptive statistics and inferential analysis (p < 0.05).
Results: The prevalence of VDD (25OHD <12 ng/mL), vitamin D insufficiency (VDI, 25OHD 12-20 ng/mL) and vitamin D sufficiency (VDS, 25OHD >20 ng/mL) was 11.2% (95% CI 8.0%-14.4%), 12.2% (95% CI 8.9%-15.5%), and 76.5% (95% CI 72.3%-80.8%) respectively. There was no difference in the mean age, head circumference, length, or weight of infants in VDD, VDI, and VDS groups. PTH was elevated when 25OHD was <12 ng/mL and normal when 25OHD was between 12-20 ng/mL. 25OHD and PTH were normal in infants whose mothers received vitamin D supplements. Infants who received <30 minutes/day of exposure to sunlight were 5 times more likely to have VDI than infants who received ≥30 minutes/day (p = 0.042).
Conclusion: The prevalence of VDD in exclusively breastfed infants at AKUHN is low. The current national policy that recommends exclusive breastfeeding of infants in the first 6 months of life appears to be effective in staving off vitamin D deficiency but those infants with < 30 minutes sunlight exposure may benefit from low dose supplemental vitamin D during times of low sunlight exposure. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | 25OHD; exclusively breastfed infants; parathyroid hormone; vitamin D; vitamin D | en_US |
dc.title | Prevalence of vitamin D deficiency in exclusively breastfed infants at a tertiary healthcare facility in Nairobi, Kenya | en_US |
dc.type | Article | en_US |