dc.contributor.author | Gitonga, Lawrence K | |
dc.contributor.author | Boru, Waqo G | |
dc.contributor.author | Kwena, Arthur | |
dc.contributor.author | Maritim, Marybeth | |
dc.contributor.author | Wamicwe, Joyce | |
dc.contributor.author | Ransom, James | |
dc.date.accessioned | 2021-09-01T12:39:30Z | |
dc.date.available | 2021-09-01T12:39:30Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Gitonga LK, Boru WG, Kwena A, Maritim M, Wamicwe J, Ransom J. Point of care testing evaluation of lateral flow immunoassay for diagnosis of cryptococcus meningitis in HIV-positive patients at an urban hospital in Nairobi, Kenya, 2017. BMC Res Notes. 2019 Dec 5;12(1):797. doi: 10.1186/s13104-019-4829-4. PMID: 31806044; PMCID: PMC6896259. | en_US |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/31806044/ | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/155400 | |
dc.description.abstract | Abstract
Objectives: The objective of this study was to evaluate the performance of lateral flow immunoassay (LFA) against latex agglutination (LA), India ink and culture in point-of-care diagnosis of cryptococcus meningitis (CM). We conducted cross-sectional study among HIV-positive patients with suspected CM at Mbagathi Hospital, Nairobi, April-July 2017.
Results: Of 124 capillary blood and serum and 99 cerebrospinal fluid (CSF) samples, LFA and LA had a concurrence on serum of 94.4%, kappa (0.88), sensitivity (100%) and specificity (91%). LFA and LA on CSF, was 97.9%, kappa (0.96), sensitivity (100%) and specificity (96%). LFA and India ink was 96.9%, kappa (0.94), sensitivity (100%) and specificity (94.1%). On CSF culture, concurrence was 72.7%, kappa (0.43), sensitivity (100%) and specificity (64%) and of LFA on capillary blood, serum and CSF was 100% with kappa (1.00), sensitivity and specificity of 100%. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | HIV; Kenya; Meningitis; Point of care. | en_US |
dc.title | Point of care testing evaluation of lateral flow immunoassay for diagnosis of cryptococcus meningitis in HIV-positive patients at an urban hospital in Nairobi, Kenya, 2017 | en_US |
dc.type | Article | en_US |