Antiplasmodial Biflavanones from the Stem Bark of Garcinia buchananii Engl.
Omole, Ruth A
Moshi, Mainen J
Malebo, Hamisi M
Gathirwa, Jeremiah W
Oriko, Richard O
Omosa, Leonida Kerubo
Midiwo, Jacob Ogweno
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Introduction: Plants of the genus Garcinia are traditionally used treat a range of infectious and non-infectious diseases. Garcinia species are reported to have been shown to have a range of biological activities including cytotoxicity antimicrobial, antifungal, antioxidant, antimalarial and HIV-1 protease inhibitory activity among others. Methods: Solvent extraction was done using CH2 Cl2 : MeOH (1:1). Isolation was done using column chromatography with silica gel as the stationery phase and ethyl acetate and n-hexane used as mobile phase in increasing polarity. Thin layer chromatography was used to monitor the isolation. Structure elucidation was done using nuclear magnetic resonance and mass spectroscopic techniques. Chloroquine resistant (W2) and chloroquine sensitive (D6) P. falciparum strains were used for antiplasmodial assay. Results: Further bioassay guided fractionation of a CH2 Cl2 : MeOH (1:1) extract of Garcinia buchananii led to the isolation of two already reported biflavanones, isogarcinol (1) and guttiferone (2) with promising antiplasmodial activity against a chloroquine resistant (W2) Plasmodium falciparum strain with an IC50 of 2.8 ± 0.90 µg/mL for compound 1 and IC50 of 3.94 ± 0.38 µg/mL for compound 2. Compounds 1 and 2 also exhibited moderate activity against the chloroquine sensitive (D6) Plasmodium falciparum strain with IC50 of 7.03±0.60 and 10.64±4.50 µg/mL, respectively. Conclusion: The results provide proof to support the use of G. buchananii by the indigenous community for antimalarial therapy.
CitationOmole RA, Moshi MJ, Heydenreich M, Malebo HM, Gathirwa JW, Oriko RO, Omosa LK, Midiwo JO. "Antiplasmodial Biflavanones from the Stem Bark of Garcinia buchananii Engl." Pharmacognosy Communications. 2019;9(3):96-99.
University of Nairobi
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