dc.contributor.author | Neumann, CG | |
dc.contributor.author | Bwibo, NO | |
dc.contributor.author | Siekmann, JH | |
dc.contributor.author | McLean, ED | |
dc.contributor.author | Browdy, B | |
dc.contributor.author | Drorbaugh, N | |
dc.date.accessioned | 2013-04-15T09:00:54Z | |
dc.date.available | 2013-04-15T09:00:54Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | East Afr Med J. 2008 Nov;85(11):544-9 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/19413207 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/15952 | |
dc.description.abstract | OBJECTIVE:
To compare the diagnostic performance of microscopy using Giemsa-stained thick and thin blood smears to a rapid malaria dipstick test (RDT) in detecting P. falciparum malaria in Kenyan school children.
DESIGN:
Randomised, controlled feeding intervention trial from 1998-2001.
SETTING:
Rural Embu district, Kenya. The area is considered endemic for malaria, with four rainy seasons per year. Chloroquine resistance was estimated in 80% of patients. Children had a spleen rate of 45%.
SUBJECTS:
A sample of 515 rural Kenyan primary school children, aged 7-11 years, who were enrolled in a feeding intervention trial from 1998-2001.
MAIN OUTCOME MEASURES:
Percent positive and negative P. falciparum malaria status, sensitivity, specificity and positive and negative predictive values of RDT
RESULTS:
For both years, the RDT yielded positive results of 30% in children compared to microscopy (17%). With microscopy as the "gold standard", RDT yielded a sensitivity of 81.3% in 1998 and 79.3% in 2000. Specificity was 81.6% in 1998 and 78.3% in 2000. Positive predictive value was 47.3% in 1998 and 42.6% in 2000, and negative predictive value was 95.6% in 1998 and 94.9% in 2000.
CONCLUSION:
Rapid diagnostic testing is a valuable tool for diagnosis and can shorten the interval for starting treatment, particularly where microscopy may not be feasible due to resource and distance limitations | en |
dc.language.iso | en | en |
dc.title | Comparison of blood smear microscopy to a rapid diagnostic test for in-vitro testing for P. falciparum malaria in Kenyan school children | en |
dc.type | Article | en |
local.publisher | Department of Paediatrics, School of Public Health, University of California, Los Angeles, CA 90095-1772, USA | en |
local.publisher | Department of Paediatrics, University of Nairobi, Kenya. | en |