Reversible Effect of Testosterone on the Morphology of the Coronary Artery in Adult Male Rabbits;an Interventional Study

Abstract

Background; Male hypogonadism, marked by low serum levels of testosterone, is a relatively common endocrine disorder and its prevalence differs among populations. Declining quantities of serum testosterone have been linked with increased risk for cardiovascular diseases. On the contrary, a physiological rise in testosterone level is protective against cardiovascular diseases and ameliorates ongoing cardiovascular events. Androgens influence the cardiovascular system through multipronged mechanisms, one of them being the induction of histomorphological changes in the vascular wall. Varying levels of androgens have been associated with structural modifications in vessels such as the carotid and the aorta in various studies. Of note, studies show a correlation of reduced testosterone levels with an increase in intimal-medial thickness, connective tissue density of the vascular wall, and reduced luminal diameter in key vessels. Physiological studies on the efficacy of testosterone on various vascular beds illustrate non-uniformity, suggesting that its effect on the vascular structure may also not be homogenous..................................................................................