| dc.contributor.author | Munenge, Rahab W. | |
| dc.date.accessioned | 2013-04-16T08:23:47Z | |
| dc.date.available | 2013-04-16T08:23:47Z | |
| dc.date.issued | 1998 | |
| dc.identifier.citation | Pharmaceutical Biology | en |
| dc.identifier.uri | http://informahealthcare.com/doi/abs/10.1076/phbi.36.2.88.4605 | |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16089 | |
| dc.description.abstract | A 70% methanol extract of leaves of Psiadia punculata caused a fall of blood pressure in anaesthetised rats. After a 10 µg dose of the extract, systolic, diastolic and mean blood pressures fell by 16, 13 and 14%, respectively, below the pre-drum levels. The fall of systolic, diastolic and mean blood pressures in anaesthetised rats were 23, 14 and 19%, respectively, after a 60 µg dose of the extract. The post-drug blood pressure levels were significantly lower (P < 0.001) than the pre-drug levels. The plant extract showed neuromuscular blocking activity on isolated rat phrenic nerve diaphragm which was dose-related. The extract had bronchodilating properties on isolated guinea pig trachea, which was dose-dependent. The treatment of the rabbit jejunum with the plant extract in a calcium free Krebs solution, inhibited Ca 2+ ions to restore jejunum contractions, suggesting the extract had calcium channel blocking activity similar to that of verapamil, a known calcium channel blocker | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Vol. 36, No. 2, Pages 88-92 (1998); | |
| dc.title | Pharmacological Activities of Psiadia punculata | en |
| dc.type | Article | en |
| local.publisher | Departmnent of Medicine, College of Health Sciences, University of Nairobi | en |
