A new gnidiflavanone-flavonol dimer and other constituents from Gnidia apiculata
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Date
2022-04Author
Kamau, Rahab W
Masila, Veronica M
Midiwo, Jacob O
Mgani, Quintino A
Kumarihamy, Mallika
Wang, Mei
Zhao, Jianping
Muhammad, Ilias
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ArticleLanguage
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A new 3,8''-flavanone-flavonol dimer gnidiflavanone-flavonol (1) and 10 known compounds (2-11), including four rare primula-type flavones 2-5, were isolated from the roots of Gnidia apiculata. Compounds 2-5 and 7 were reported for the first time from the plant family Thymelaeceae. Structures of the isolated compounds were established by spectroscopic data, including 1D and 2D NMR (COSY, HMBC, HSQC and ROESY) and mass spectrometry, as well as by the comparison with literature data. The crude roots extract and isolated compounds were evaluated for antimicrobial and antiplasmodial activities. Among isolated compounds, 6-hydroxyflavone (4) and 6-O-acetylflavone (4a) showed antiplasmodial activity against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum.
Citation
Kamau RW, Masila VM, Midiwo JO, Mgani QA, Kumarihamy M, Wang M, Zhao J, Muhammad I. A new gnidiflavanone-flavonol dimer and other constituents from Gnidia apiculata. Nat Prod Res. 2022 Apr 8:1-8. doi: 10.1080/14786419.2022.2062349. Epub ahead of print. PMID: 35392742.Publisher
University of Nairobi
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Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
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