dc.contributor.author | Matheka, Charles D | |
dc.date.accessioned | 2022-11-08T06:10:26Z | |
dc.date.available | 2022-11-08T06:10:26Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/161640 | |
dc.description.abstract | Background: Recurrent Respiratory Papillomatosis is an aggressive, recurrent, difficult to
manage disease, caused by Human Papillomavirus. It affects both children and adults.
Determination of the human papilloma virus genotype is of prognostic value in management
of recurrent respiratory papillomatosis.
Objective: To determine human papilloma virus genotypes and correlate with severity of
disease in patients with recurrent respiratory papillomatosis at Kenyatta National Hospital.
Study design: Hospital based cross-sectional study
Study site: The study was conducted at Kenyatta National Hospital Ear, Nose and Throat
department, operating theatre and University of Nairobi Kenya Aids Vaccine Initiativeinstitute
of clinical research laboratory.
Study Population: Patients diagnosed with recurrent respiratory papillomatosis.
Methodology: Forty patients diagnosed with recurrent respiratory papillomatosis were
recruited. Patients history was taken. Two biopsy samples were taken, one for Human
papillomavirus genotyping and the other for histopathology. Disease severity was classified
as aggressive or non-aggressive using Doyle criteria.
Data analysis: SPSS version 23.0 statistical software was used to analyze data. Descriptive
analysis was performed on all variables and summarized into frequency, tables and charts.
Pearson chi square was used to test association between independent variables.
Results: There were 25(62.5%) male and 15(37.5%) female patients. HPV 6 was isolated in
67.5% patients and HPV 11 in 32.5% with no co-infection. The patients had an age range
between 3 to 66 years where majority (92.5%) had JORRP and 7.5 % had AORRP. 40% had
aggressive disease while 60% had non-aggressive disease. HPV 11 was found in 81.3% of
patients with aggressive disease and HPV 6 in 18.8%. There was a positive correlation
between HPV 11 and disease aggression (p<0.001).
Conclusion: HPV 6 is the most common (67.5%) HPV genotype in patients with RRP at
KNH and HPV 11 is associated with aggressive disease. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.title | Human Papilloma Virus Genotypes in Recurrent Respiratory Papillomatosis Patients at Kenyatta National Hospital | en_US |
dc.type | Thesis | en_US |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |