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Anti-HIV crotocascarin ω from Kenyan Croton dichogamus

dc.contributor.authorTerefe, Ermias M
dc.contributor.authorOkalebo, Faith A
dc.contributor.authorDerese, Solomon
dc.contributor.authorMuriuki, Joseph
dc.contributor.authorMas-Claret, Eduard
dc.contributor.authorLangat, Moses K
dc.date.accessioned2022-11-09T07:17:24Z
dc.date.available2022-11-09T07:17:24Z
dc.date.issued2022-10
dc.identifier.citationTerefe EM, Okalebo FA, Derese S, Muriuki J, Mas-Claret E, Langat MK. Anti-HIV crotocascarin ω from Kenyan Croton dichogamus. Nat Prod Res. 2022 Oct 24:1-8. doi: 10.1080/14786419.2022.2134998. Epub ahead of print. PMID: 36278900.en_US
dc.identifier.urihttp://erepository.uonbi.ac.ke/handle/11295/161657
dc.description.abstractAn anti-HIV methanol-soluble fraction of a 1:1 CH2Cl2:CH3OH extract of twigs of a Kenyan Croton dichogamus yielded seven compounds, the new crotocascarin ω (1), the known β-oplopanone (2), dihydroconiferyl acetate (3), 3'(4''-hydroxyphenyl)-propyl benzoate (4), lupeol, sitosterol and stigmasterol. Crotocascarin ω (90%) inhibited HIV-1 replication with an IC50 value of 5.3 nM, and the compound was cytotoxic towards MT-4 cells presenting an IC50 value of 84 µM. In silico modelling showed that the anti-HIV activity for compound 1 could be through the HIV-1 protease inhibition.en_US
dc.language.isoenen_US
dc.publisherUniversity of Nairobien_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject3’(4’’-hydroxyphenyl)-propyl benzoate; Anti-HIV activity; Croton dichogamus; crotocascarin ω; dihydroconiferyl acetate; β-oplopanone.en_US
dc.titleAnti-HIV crotocascarin ω from Kenyan Croton dichogamusen_US
dc.typeArticleen_US


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States