dc.contributor.author | Peterson TA. | |
dc.contributor.author | Kimani J. | |
dc.contributor.author | Wachihi C. | |
dc.contributor.author | Bielawny T. | |
dc.contributor.author | Mendoza, L | |
dc.contributor.author | Thavaneswaran, S | |
dc.contributor.author | Narayansingh, MJ | |
dc.contributor.author | Kariri, T | |
dc.contributor.author | Liang, B | |
dc.contributor.author | Ball, TB | |
dc.contributor.author | Ngugi, Elizabeth N | |
dc.contributor.author | Plummer, FA | |
dc.contributor.author | Luo, M | |
dc.date.accessioned | 2013-04-17T04:56:23Z | |
dc.date.available | 2013-04-17T04:56:23Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Tissue Antigens.2013 Feb;81(2):93-107 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/23330720 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16167 | |
dc.description.abstract | Class I human leukocyte antigens (HLA) play an important role in the adaptive immune response by presenting antigens to CD8+ T cells. Studies have reported that several HLA class I alleles are associated with differential disease progression in human immunodeficiency virus (HIV)-infected individuals, however, few class I associations with resistance or susceptibility to HIV-1 infection have been reported. We typed HLA-A, -B and -C of >1000 women enrolled in the Pumwani Sex Worker Cohort using a sequence-based typing method. Kaplan–Meier analysis was used to identify alleles influencing seroconversion and disease progression to acquired immune deficiency syndrome (CD4 < 200/mm3). A*01 (P = 0.020), C*06:02 (P = 0.042) and C*07:01 (P = 0.050) are independently associated with protection from seroconversion. Women with any of these alleles are less likely to seroconvert [P = 0.00001, odds ratio (OR): 0.503, 95% confidence interval (CI): 0.320–0.790]. Conversely, A*23:01 (P = 0.004), B*07:02 (P = 0.003) and B*42:01 (P = 0.025) are independently associated with rapid seroconversion. Women with any of these alleles are twice as likely to seroconvert (P = 0.002, OR: 2.059, 95% CI: 1.290–3.285). The beneficial alleles confer threefold protection from seroconversion when compared with the susceptible alleles (P = 0.000001, OR: 0.268, 95% CI: 0.132–0.544). B*07:02 is the contributing allele, within the B7 supertype, to the rapid seroconversion. A*74:01 (P = 0.04/P = 0.006), B*14 (P = 0.003/P = 0.003) and B*57:03 (P = 0.012/P = 0.038) are independently associated with slower CD4+ decline and LTNP phenotype, while B*07:02 (P = 0.020), B*15:10 (P = 0.022) and B*53:01 (P = 0.007) are independently associated with rapid CD4+ T-cell decline. B7 supertype (P = 0.00006), B*35*-Py (P = 0.028) and B*35-Px (P = 0.001) were also significantly associated with rapid CD4+ T-cell decline. Understanding why these HLA class I alleles are associated with protection/susceptibility to HIV-1 acquisition and disease progression could contribute to the development of effective prophylactic and therapeutic vaccines for HIV-1 | en |
dc.language.iso | en | en |
dc.subject | Differential human immunodeficiency virus-1 seroconversion; | en |
dc.subject | Differential human immunodeficiency virus-1 seroconversion; | en |
dc.subject | Human leukocyte antigen class I association; | en |
dc.subject | Natural resistance to human immunodeficiency virus-1 infection; | en |
dc.subject | Pumwani Sex Worker Cohort | en |
dc.title | HLA class I associations with rates of HIV-1 seroconversion and disease progression in the Pumwani Sex Worker Cohort. | en |
dc.type | Article | en |
local.publisher | HIV and Human Genetics, National Microbiology Laboratory, Winnipeg, MB, Canada. | en |
local.publisher | Department of Medical Microbiology, University of Nairobi | en |
local.publisher | Department of Community Health, University of Nairobi, | en |
local.publisher | Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada | en |