dc.contributor.author | Othieno-Abinya, N. A. | |
dc.contributor.author | Waweru, A. | |
dc.contributor.author | Nyabola, L. O. | |
dc.date.accessioned | 2013-04-17T05:54:46Z | |
dc.date.issued | 2007-01 | |
dc.identifier.citation | East Afr Med J.. | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16178 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/17633579 | |
dc.description.abstract | OBJECTIVE: To evaluate chemotherapy induced myelosuppression, its management and outcome. DESIGN: Retrospective analysis of patients aged 13 years and above. SETTING: Hurlingham Oncology Clinic and the Nairobi Hospital during the period of June 1998 to June 2003. SUBJECTS: Two hundred and two solid tumour and lymphoma patients treated with pulsed chemotherapy at Hurlingham Oncology Clinic and those treated by the same service at the Nairobi Hospital. RESULTS: Two hundred patients were evaluable for nadir blood counts. World Health Organisation (WHO) grade 3 neutropaenia complicated 57 (26.1%), and grade 4 complicated 56 (25.7%) treatments. Grade 0 neutropaenia was seen in 40 (18.4%) treatments, 33 having included prophylactic Granulocyte-Colony Stimulating Factors (G-CSF). Neutropaenia was worst following the first and sixth courses, and repeated second line courses but the difference was not statistically significant (p = 0.154). Fever complicated 6 grade 3 and 21 grade 4 neutropenic episodes (23.1% of 117 evaluable). Twenty eight patients were hospitalised because of severe neutropaenia (23 febrile, and five afebrile initially but with absolute neutrophil counts < 0.01 x 10(9)/litre). Eight of them died, six attributable to infections (21.4% mortality) and two attributed to other causes. Median time to neutrophil recovery to 21.5 x 10(9)/litre was three days with a mean of 4.6 days. Anaemia and thrombocytopaenia were not commonly experienced. CONCLUSION: Prophylactic use of G-CSF may have prevented severe neutropaenia and its use in severe neutropaenia may have reduced the duration and severity of neutropaenia but the mortality rate for febrile neutropaenia remained high. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Vol. 84(1):8-15 (2007); | |
dc.title | Chemotherapy induced myelosuppression | en |
dc.type | Article | en |
local.publisher | Department of Medicine. College of Health Sciences. University of Nairobi | en |