Resistance to HIV-1 infection among African sex workers is associated with global hyporesponsiveness in interleukin 4 production.
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Date
2001Author
Trivedi HN.
Plummer, FA
Anzala, AO
Njagi E
Bwayo, JJ
Ngugi, Elizabeth N
Embree JE.
Hayglass KT.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
We previously identified HIV-1 resistant prostitutes who remain persistently HIV-1 PCR- and
antibody-negative despite continued heavy exposure to HIV-1 through sex work. We hypothesized
that differences in virus-specific cytokine responses are associated with resistance vs. susceptibility
to infection. Although polyclonal activation failed to reveal such differences, antigen-mediated
activation of peripheral blood mononuclear cells (PBMC) in primary culture by using intact HIVIIIB
demonstrates that resistance is associated with enhanced virus-
d markedly
reduced IL-4 responses relative to those seen in HIV-1 seropositive prostitutes (CDC stage A1,
CD4>500/ml). No changes were detectable in HIV-stimulated interleukin (IL) 10 and IL-13
production, but IL-5 responses were somewhat increased in resistant sex workers. Moreover, the IL-
4 responses of HIV-1 resistant women to a panel of unrelated recall antigens were more than 20-fold
reduced relative to HIV-infected prostitutes or those of healthy Kenyan women not involved in sex
work. Thus, resistant women differ from seropositive-infected women and healthy controls by
exhibiting a profound global hyporesponsiveness in their capacity to generate IL-4 responses.
URI
http://www.ncbi.nlm.nih.gov/pubmed/11481233http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16195
http://www.fasebj.org/content/early/2001/08/02/fj.00-0619fje.long
Citation
FASEB J. 2001 Aug;15(10):1795-7Publisher
Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada R3E 0W3 Department of Community Health, University of Nairobi,
Collections
- Faculty of Health Sciences (FHS) [10378]