dc.contributor.author | Anzala, AO | |
dc.contributor.author | Simonsen, JN | |
dc.contributor.author | Kimani J. | |
dc.contributor.author | Ball TB. | |
dc.contributor.author | Nagelkerke, NJ | |
dc.contributor.author | Rutherford J | |
dc.contributor.author | Ngugi, Elizabeth N | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Plummer, FA | |
dc.date.accessioned | 2013-04-17T07:19:24Z | |
dc.date.available | 2013-04-17T07:19:24Z | |
dc.date.issued | 2000 | |
dc.identifier.citation | J Infect Dis. 2000 Aug;182(2):459-66. Epub 2000 Jul 12 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/10915076 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16208 | |
dc.description.abstract | In Kenya, the median incubation time to AIDS in seroconverting sex workers is 4 years;
this incubation time is specific to female sex workers.We studied the influence of acute sexually transmitted infections (STIs) on several immunologic parameters in 32 human immunodeficiency virus type 1 (HIV-1)–positive and 10 HIV-1–negative women sex workers who were followed for 1–5 months. Plasma cytokines, soluble cytokine receptors, CD4 and CD8 T cell counts, and HIV-1 plasma viremia were quantitated before, during, and after episodes of STI. Increases in interleukin (IL)–4, IL-6, IL-10, soluble tumor necrosis factor (TNF)–a, and viremia and a decline in CD4+ T cell counts occurred during gonococcal cervicitis and returned to baseline after treatment. Increases in viremia correlated with increased IL-4 and decreased IL-6 concentrations. Similar changes were seen among women with acute pelvic inflammatory disease. Acute bacterial STI resulted in increased HIV-1 viremia. This may be mediated through increased inflammatory cytokines or through modulation of immune responses that control HIV-1 viremia. | en |
dc.language.iso | en | en |
dc.title | Acute sexually transmitted infections increase human immunodeficiency virus type 1 plasma viremia, increase plasma type 2 cytokines, and decrease CD4 cell counts | en |
dc.type | Article | en |
local.publisher | Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada | en |
local.publisher | Department of Community Health, University of Nairobi, | en |
local.publisher | Department of Medical Microbiology, University of Nairobi | en |