dc.contributor.author | Kaul R. | |
dc.contributor.author | Kimani J | |
dc.contributor.author | Nagelkerke NJ. | |
dc.contributor.author | Plummer, FA | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Brunham RC. | |
dc.contributor.author | Ngugi, Elizabeth N | |
dc.contributor.author | Ronald, A | |
dc.date.accessioned | 2013-04-17T08:04:02Z | |
dc.date.available | 2013-04-17T08:04:02Z | |
dc.date.issued | 1997 | |
dc.identifier.citation | Sex Transm Dis. 1997 Aug;24(7):387-92 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/9263358 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16229 | |
dc.description.abstract | BACKGROUND AND OBJECTIVES: Genital ulcer disease (GUD) is a major risk factor for human immunodeficiency virus (HIV) transmission. Cross-sectional studies have suggested that HIV infection may itself predispose to genital ulceration (GU). GOAL: To prospectively study the effects of HIV type 1 (HIV-1) infection and behavioral variables on GU incidence. METHODS: A cohort of 302 Kenyan female sex-workers was established in April 1991. Women were scheduled for assessment every 2 weeks, and bloods were collected every 6 months for HIV serology, rapid plasma reagin (RPR) and CD4 counts. Logistic regression was used to study risk factors for incident genital ulcers. RESULTS: 189 women (62.5%) had at least one incident ulcer over 24.3 +/- 15.3 months. GU incidence was higher in seropositive than initially seronegative women (82% vs. 48%; odds ratio [OR]) = 4.33; P < 0.01). Only HIV-1 seropositivity (OR = 3.42), a CD4 count < 200/ml (OR = 1.94), and oral contraceptive use (OR = 1.35) were associated (P < 0.05) with GU incidence in regression analysis. For those ulcers where an etiology was actively sought, Hemophilus ducreyi was confirmed in 54 (19%) of cases, and syphilis in 30 (29%). CONCLUSION: GU incidence in Kenyan sex workers is independently affected by HIV-1 serostatus, degree of immunosuppression, and oral contraceptive use. | en |
dc.language.iso | en | en |
dc.title | Risk factors for genital ulcerations in Kenyan sex workers. The role of human immunodeficiency virus type 1 infection. | en |
dc.type | Article | en |
local.publisher | Department of Medical Microbiology, University of Nairobi, Kenya | en |
local.publisher | Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada | en |
local.publisher | Department of Community Health, University of Nairobi, | en |
local.publisher | Departmrnt of infectious Disease, University of Toronto, Canada | en |