Rapid progression to disease in African sex workers with human immunodeficiency virus type 1 infection

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Date
1995Author
Anzala, OA
Nagelkerke, NJ
Bwayo, JJ
Holton D.
Moses S.
Ngugi, Elizabeth N
Ndinya-Achola, JO
Plummer, FA
Type
ArticleLanguage
jaMetadata
Show full item recordAbstract
From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-1-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk = .64, P < .05). The incubation time of HIV-1-related disease is extremely short in this population.
URI
www.ncbi.nlm.nih.gov/whalecom0/pubmed/7876618http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16253
Citation
J Infect Dis. 1995 Mar;171(3):686-9Publisher
Department of Medical Microbiology, University of Nairobi, Kenya Department of Community Health, University of Nairobi,
Collections
- Faculty of Health Sciences (FHS) [10227]