dc.contributor.author | Begnel, Emily R | |
dc.contributor.author | Chohan, Bhavna H | |
dc.contributor.author | Ojee, Ednah | |
dc.contributor.author | Adhiambo, Judith | |
dc.contributor.author | Owiti, Prestone | |
dc.contributor.author | Ogweno, Vincent | |
dc.contributor.author | Holland, LaRinda A | |
dc.contributor.author | Fish, Carolyn S | |
dc.contributor.author | Richardson, Barbra A | |
dc.contributor.author | Khan, Adam K | |
dc.contributor.author | Maqsood, Rabia | |
dc.contributor.author | Lim, Efrem S | |
dc.contributor.author | Sadarangani, Manish | |
dc.contributor.author | Lehman, Dara A | |
dc.contributor.author | Slyker, Jennifer | |
dc.contributor.author | Kinuthia, John | |
dc.contributor.author | Wamalwa, Dalton | |
dc.contributor.author | Gantt, Soren | |
dc.date.accessioned | 2024-03-11T08:26:30Z | |
dc.date.available | 2024-03-11T08:26:30Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/36649247/ | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/164337 | |
dc.description.abstract | Background: HIV may increase SARS-CoV-2 infection risk and COVID-19 severity generally, but data are limited about its impact on postpartum women and their infants. As such, we characterized SARS-CoV-2 infection among mother-infant pairs in Nairobi, Kenya.
Methods: We conducted a nested study of 62 HIV-uninfected and 64 healthy women living with HIV, as well as their HIV-exposed uninfected (N = 61) and HIV-unexposed (N = 64) infants, participating in a prospective cohort. SARS-CoV-2 serology was performed on plasma collected between May 1, 2020-February 1, 2022 to determine the incidence, risk factors, and symptoms of infection. SARS-CoV-2 RNA PCR and sequencing was also performed on available stool samples from seropositive participants.
Results: SARS-CoV-2 seropositivity was found in 66% of the 126 mothers and in 44% of the 125 infants. There was no significant association between SARS-CoV-2 infection and maternal HIV (Hazard Ratio [HR] = 0.810, 95% CI: 0.517-1.27) or infant HIV exposure (HR = 1.47, 95% CI: 0.859-2.53). Maternal SARS-CoV-2 was associated with a two-fold increased risk of infant infection (HR = 2.31, 95% CI: 1.08-4.94). Few participants (13% mothers, 33% infants) had symptoms; no participant experienced severe COVID-19 or death. Seroreversion occurred in about half of mothers and infants. SARS-CoV-2 sequences obtained from stool were related to contemporaneously circulating variants.
Conclusions: These data indicate that postpartum Kenyan women and their infants were at high risk for SARS-CoV-2 infection and that antibody responses waned over an average of 8-10 months. However, most cases were asymptomatic and healthy women living with HIV did not have a substantially increased risk of infection or severe COVID-19. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.title | HIV and SARS-CoV-2 infection in postpartum Kenyan women and their infants | en_US |
dc.type | Article | en_US |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |