High levels of cervical HIV-1 RNA during early HIV-1 infection.
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Date
2006Author
Lavreys, L
Baeten, JM
Panteleeff, DD
Richardson, BA
McClelland, RS
Chohan, V
Mandaliya, K
Ndinya-Achola Jeckoniah O
Overbaugh, J
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Few data are available on genital tract viral replication early after HIV-1 acquisition, when infectivity is high. We compared cervical HIV-1 RNA from 60 women with paired samples from within 90 days after HIV-1 acquisition and at viral setpoint (4-24 months). Cervical HIV-1 was higher in early compared with setpoint samples (mean 3.43 versus 2.85 log10 copies/swab, P < 0.001). After adjusting for HIV-1-plasma RNA, cervical HIV-1 RNA from 30 days or less after infection was increased by 0.45 log10 copies/swab (P = 0.006).
URI
http://www.ncbi.nlm.nih.gov/pubmed/17117027http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16635
Citation
AIDS.2006 Nov 28;20(18):2389-90Publisher
Department of Medical Microbiology, University of Nairobi Department of Epidemiology, University of Washington, Seattle, Washington, USA
Collections
- Faculty of Health Sciences (FHS) [10377]