dc.contributor.author | Donoval, BA | |
dc.contributor.author | Landay, AL | |
dc.contributor.author | Moses, S | |
dc.contributor.author | Agot, K | |
dc.contributor.author | Ndinya-Achola Jeckoniah O. | |
dc.contributor.author | Nyagaya, EA | |
dc.contributor.author | MacLean, I | |
dc.contributor.author | Bailey, RC | |
dc.date.accessioned | 2013-04-25T06:00:26Z | |
dc.date.available | 2013-04-25T06:00:26Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Am J Clin Pathol. 2006 Mar;125(3):386-91 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/16613341 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16641 | |
dc.description.abstract | Numerous epidemiologic studies have found significant associations between lack of circumcision and HIV-1 acquisition in men. To our knowledge, this is the first study of human foreskin tissue that examines biologic mechanisms that increase susceptibility of uncircumcised African men to HIV-1. Foreskin specimens from 20 men with and 19 men with no history of sexually transmitted infections were examined for HIV-1 target cells. Most Langerhans cells were found in the epithelium; most CD4+ T cells and macrophages were in the submucosa. There were no differences in HIV-1 target cells between men with and those without history of sexually transmitted infections. However Langerhans cells and macrophages were more abundant in the group with a history of infection. The densities and positions of HIV-1 target cells in the foreskin tissue of these Kenyan men indicate that the inner mucosal surface of the human foreskin contains cells that make it highly susceptible to HIV infection. | en |
dc.language.iso | en | en |
dc.title | HIV-1 target cells in foreskins of African men with varying histories of sexually transmitted infections | en |
dc.type | Article | en |
local.publisher | Division of Epidemiology, School of Public Health, University of Illinois, Chicago 60612, USA | en |
local.publisher | Department of Medical Microbiology, University of Nairobi | en |