Acrodermatitis chronica atrophicans with pseudolymphomatous infiltrates.
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Date
2013-05Author
Tee SI.
Martínez-Escanamé M.
Zuriel Daniel.
Fried I.
Wolf I.
Massone C.
Cerroni L.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
n this study, we describe the clinicopathologic features of pseudolymphomatous infiltrates found within lesions of acrodermatitis chronica atrophicans (ACA). We studied 11 patients (10 females, 1 male, age range 60-88 years). The diagnosis of ACA in all cases was confirmed by clinicopathologic correlation and positive serology for Borrelia. Histopathologic examination revealed prominent, pseudolymphomatous inflammatory cell infiltrates in all cases, with 2 distinct patterns. Eight of 11 cases showed a band-like lymphocytic infiltrate, exocytosis of lymphocytes and a fibrotic papillary dermis, similar to features seen in mycosis fungoides. The other 3 cases showed dense, nodular-diffuse dermal infiltrates with many plasma cells and without germinal centers. The plasma cells expressed both kappa and lambda immunoglobulin light chains with a polyclonal pattern in all 3 cases. In conclusion, ACA may present with pseudolymphomatous infiltrates showing both a T-cell and, less frequently, a B-cell pattern. These lesions need to be distinguished from a cutaneous lymphoma. In the context of the knowledge of Borrelia-associated cutaneous lymphomas, follow-up seems advisable in these cases.
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http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16672http://www.ncbi.nlm.nih.gov/pubmed/23147352
Citation
Am J Dermatopathol. 2013 May;35(3):338-42Collections
- Faculty of Health Sciences (FHS) [10377]