dc.contributor.author | Sagar, M | |
dc.contributor.author | Lavreys, L | |
dc.contributor.author | Baeten, JM | |
dc.contributor.author | Richardson, BA | |
dc.contributor.author | Mandaliya, K | |
dc.contributor.author | Ndinya-Achola, JO | |
dc.contributor.author | Kreiss, JK | |
dc.contributor.author | Overbaugh, J | |
dc.date.accessioned | 2013-04-25T07:02:38Z | |
dc.date.available | 2013-04-25T07:02:38Z | |
dc.date.issued | 2004 | |
dc.identifier.citation | AIDS. 2004 Mar 5;18(4):615-9 | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/15090766 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16675 | |
dc.description.abstract | BACKGROUND:
Our previous studies have shown that the majority of African women were infected with multiple HIV-1 genetic variants, while in the remaining women only a single viral genotype was detected early in infection. Infection with multiple viral variants was associated with higher plasma HIV-1 RNA levels and faster CD4 T-cell decline.
METHOD:
Socio-behavioral characteristics, use of hormonal contraceptives, and the presence of sexually transmitted diseases were prospectively assessed at approximately monthly intervals around the time of HIV-1 acquisition in female sex workers in Kenya. We assessed the relationship between these factors and HIV-1 genetic complexity early in infection.
RESULTS:
One hundred and fifty-six women were included in this analysis, of whom 89 had multiple viral genotypes and 67 had a single genotype at primary infection. Women with multiple variants were more likely to have a genital tract infection [odds ratio (OR), 4.7; 95% confidence interval (CI), 1.4-18.1] or to be using hormonal contraceptives (OR, 2.7; 95% CI, 1.3-5.6) at the time of their infection than those with a single variant. In multivariate analyses, these factors were independent predictors of early HIV-1 genetic complexity, and the presence of multiple viral variants early in infection remained significantly associated with a higher steady state plasma HIV-1 RNA level.
CONCLUSION:
The presence of genital tract infections and hormonal contraceptive use at the time of transmission were associated with the acquisition of multiple HIV-1 variants. | en |
dc.language.iso | en | en |
dc.title | Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population | en |
dc.type | Article | en |
local.publisher | Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, | en |
local.publisher | Department of Medical Microbiology, University of Nairobi | en |