dc.contributor.author | Lavreys, L | |
dc.contributor.author | Baeten, JM | |
dc.contributor.author | Kreiss, JK | |
dc.contributor.author | Richardson, BA | |
dc.contributor.author | Chohan, BH | |
dc.contributor.author | Hassan, W | |
dc.contributor.author | Panteleeff, DD | |
dc.contributor.author | Mandaliya, K | |
dc.contributor.author | Ndinya-Achola Jeckoniah O | |
dc.contributor.author | Overbaugh, J | |
dc.date.accessioned | 2013-04-25T07:21:08Z | |
dc.date.available | 2013-04-25T07:21:08Z | |
dc.date.issued | 2004 | |
dc.identifier.citation | J Infect Dis. 2004 Jan 15;189(2):303-11 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/14722896 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16683 | |
dc.description.abstract | We examined the association between host factors present near the time of human immunodeficiency virus type 1 (HIV-1) acquisition and subsequent virus loads, in a prospective cohort study of women in Mombasa, Kenya. Women were prospectively followed monthly before HIV-1 infection. One hundred sixty-one commercial sex workers who became infected with HIV-1 were followed for a median of 34 months, and 991 plasma samples collected > or =4 months after infection were tested for HIV-1 RNA. The median virus set point at 4 months after infection was 4.46 log10 copies/mL, and the average virus load increase during subsequent follow-up was 0.0094 log10 copies/mL/month. In a multivariate analysis that controlled for sexual behavior, the use of the injectable contraceptive depot medroxyprogesterone acetate (DMPA) at the time of HIV-1 infection was associated with a higher virus set point, and the presence of genital ulcer disease (GUD) during the early phase of HIV-1 infection was associated with greater change in virus load during follow-up. These findings suggest that, in women, the use of DMPA and the presence of GUD during the early phase of HIV-1 infection may influence the natural course of infection. | en |
dc.language.iso | en | en |
dc.title | Injectable contraceptive use and genital ulcer disease during the early phase of HIV-1 infection increase plasma virus load in women. | en |
dc.type | Article | en |
local.publisher | Department of Epidemiology, Medicine, and Biostatistics, University of Washington, Seattle, Washington 98104-2499, USA | en |
local.publisher | Department of Medical Microbiology, University of Nairobi | en |