dc.contributor.author | Baeten, JM | |
dc.contributor.author | McClelland, RS | |
dc.contributor.author | Overbaugh, J | |
dc.contributor.author | Richardson, BA | |
dc.contributor.author | Emery, S | |
dc.contributor.author | Lavreys, L | |
dc.contributor.author | Mandaliya, K | |
dc.contributor.author | Bankson, DD | |
dc.contributor.author | Ndinya-Achola Jeckoniah O. | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Kreiss, JK | |
dc.date.accessioned | 2013-04-25T09:04:06Z | |
dc.date.available | 2013-04-25T09:04:06Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | J Infect Dis. 2002 Apr 15;185(8):1187-91 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/11930332 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16730 | |
dc.description.abstract | Observational studies have associated vitamin A deficiency with vaginal shedding of human immunodeficiency virus (HIV) type 1-infected cells and mother-to-child HIV-1 transmission. To assess the effect of vitamin A supplementation on vaginal shedding of HIV-1, a randomized, double-blind, placebo-controlled trial of 6 weeks of daily oral vitamin A (10,000 IU of retinyl palmitate) was conducted among 400 HIV-1-infected women in Mombasa, Kenya. At follow-up, there was no statistically significant difference in the prevalence of HIV-1 DNA (18% vs. 21%, P=.4) or the quantity of HIV-1 RNA (3.12 vs. 3.00 log(10) copies/swab, P=1.0) in vaginal secretions of women receiving vitamin A, compared with women receiving placebo. No significant effect of supplementation on plasma HIV-1 load or CD4 or CD8 cell counts was observed, and no effect was seen among women who were vitamin A deficient at baseline. Vitamin A supplementation is unlikely to decrease the infectivity of women infected with HIV-1. | en |
dc.language.iso | en | en |
dc.title | Vitamin A supplementation and human immunodeficiency virus type 1 shedding in women: results of a randomized clinical trial. | en |
dc.type | Article | en |
local.publisher | Department of Epidemiology, University of Washington | en |
local.publisher | Department of Medical Microbiology, University of Nairobi | en |