dc.contributor.author | Luscher, MA | |
dc.contributor.author | Choy, G | |
dc.contributor.author | Njagi, E | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Anzala Aggrey O. | |
dc.contributor.author | Ndinya-Achola Jeckoniah O. | |
dc.contributor.author | Ball, TB | |
dc.contributor.author | Wade, JA | |
dc.contributor.author | Plummer, FA | |
dc.contributor.author | Barber, BH | |
dc.contributor.author | MacDonald, KS | |
dc.date.accessioned | 2013-04-25T12:45:49Z | |
dc.date.available | 2013-04-25T12:45:49Z | |
dc.date.issued | 1998 | |
dc.identifier.citation | AIDS Res Hum Retroviruses. 1998 Jan 20;14(2):109-15 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/9462920 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16824 | |
dc.description.abstract | In an effort to identify an immunological basis for natural resistance to HIV-1 infection, we have examined serum antibody responses to HLA class I antigens in female prostitutes of the Nairobi Sex Workers Study. Anti-HLA antibodies are known to block HIV infectivity in vitro and can be protective against SIV challenge in macaques immunized with purified class I HLA. Thus, it was postulated that broadly cross-reactive alloantibodies recognizing common HLA alleles in the client population might contribute to the prevention of heterosexual transmission of HIV. In fact, 12% of the women were found to have serum IgG antibodies against class I alloantigens. However, this alloantibody did not correlate with the HIV status of the women and was found in a similar proportion of HIV-positive and HIV-resistant women. The observed levels of alloantibody did not increase with HIV infection in susceptible individuals, suggesting that potential antigenic mimicry between HIV and host HLA class I antigens does not significantly increase levels of anti-class I antibodies. The lack of correlation between serum anti-allo-class I HLA antibodies and the risk of sexual transmission indicates that this humoral immune response is unlikely to be the natural mechanism behind the HIV-resistance phenotype of persistently HIV-seronegative women. This result, however, does not preclude the further investigation of alloimmunization as an artificial HIV immunization strategy. | en |
dc.language.iso | en | en |
dc.title | Naturally occurring IgG anti-HLA alloantibody does not correlate with HIV type 1 resistance in Nairobi prostitutes | en |
dc.type | Article | en |
local.publisher | Department of Immunology, University of Toronto, The Toronto Hospital, Canada. | en |
local.publisher | Department of Medical Microbiology, University of Nairobi | en |