Evaluation of Acute Morbidity and Quality of Life among head and neck cancer patients treated with radical radiotherapy
dc.contributor.author | Solomon, M. M | |
dc.contributor.author | Onyango, J.F, | |
dc.contributor.author | Nyabola, L.O | |
dc.contributor.author | Opiyo, A | |
dc.date.accessioned | 2013-04-25T13:04:33Z | |
dc.date.available | 2013-04-25T13:04:33Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | East Afr Med J 2009; 86: 173 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16834 | |
dc.description.abstract | Mefloquine pharmacokinetics were studied in Kenyan African normal volunteers and in patients with severe acute attack of Plasmodium falciparum malaria. Peak concentrations were achieved in both groups at 20-24 hours. The mean half-life of elimination was 385 +/- 150 hours (mean +/- SD) in normal subjects while in severe malaria it was 493 +/- 215 hours which was significantly longer (P less than or equal to 0.001). The volume of distribution was significantly smaller in severe malaria where it was 30.76 +/- 10.50 l/kg (mean +/- SD) while in the normal subjects it was 40.90 +/- 20.70 l/kg (mean +/- SD) (P less than or equal to 0.001). The total body clearance in severe malaria was 3.75 +/- 1.51 l/h (mean +/- SD). This was significantly lower than in the normal subjects where it was 5.15 +/- 1.50 l/h (mean +/- SD) (P less than or equal to 0.001). | en |
dc.language.iso | en | en |
dc.title | Evaluation of Acute Morbidity and Quality of Life among head and neck cancer patients treated with radical radiotherapy | en |
dc.type | Article | en |
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