Increased risk of infection with human immunodeficiency virus type 1 among uncircumcised men presenting with genital ulcer disease in Kenya
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Date
1996Author
Tyndall, MW
Ronald, AR
Agoki, E
Malisa, W
Bwayo, JJ
Ndinya-Achola Jeckoniah O.
Moses, S
Plummer, FA
Type
ArticleMetadata
Show full item recordAbstract
The factors responsible for the explosive spread of human immunodeficiency virus type 1 (HIV-1) in sub-Saharan Africa continue to be identified and debated. One of the most controversial factors has been male circumcision. This cross-sectional study was conducted to measure the association between circumcision status and infection with HIV-1 among men with genital ulcer disease. Eight hundred and ten men participated in the study, of whom 190 (23%) were HIV-1-positive. A logistic regression model adjusted for behavioral and historical showed that HIV-1 positivity was independently associated with being uncircumcised (adjusted odds ratio [OR], 4.8; 95% confidence interval [CI], 3.3-7.2) and with a history of urethral discharge (adjusted OR, 2.0; 95% CI, 1.4-2.8). This association could not be explained by measures of sexual exposure to HIV-1 among this population. Male circumcision should be considered as an intervention strategy for AIDS control.
URI
www.ncbi.nlm.nih.gov/whalecom0/pubmed/8879763http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16859
Citation
Clin Infect Dis. 1996 Sep;23(3):449-53.Publisher
Department of Medical Microbiology, University of Nairobi, Kenya
Collections
- Faculty of Health Sciences (FHS) [10378]