dc.contributor.author | Moss, GB | |
dc.contributor.author | Overbaugh, J | |
dc.contributor.author | Welch, M | |
dc.contributor.author | Reilly, M | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Plummer, FA | |
dc.contributor.author | Ndinya-Achola Jeckoniah O. | |
dc.contributor.author | Malisa, MA | |
dc.contributor.author | Kreiss, JK | |
dc.date.accessioned | 2013-04-25T14:16:30Z | |
dc.date.available | 2013-04-25T14:16:30Z | |
dc.date.issued | 1995 | |
dc.identifier.citation | J Infect Dis. 1995 Dec;172(6):1469-74 | en |
dc.identifier.uri | www.ncbi.nlm.nih.gov/whalecom0/pubmed/7594704 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16873 | |
dc.description.abstract | To evaluate the prevalence and correlates of human immunodeficiency virus (HIV)-infected cells in urethral secretions, samples were collected from 106 HIV-seropositive men with and without urethritis. HIV DNA was detected by polymerase chain reaction in 27% of 184 urethral specimens and was associated with CD4 cell depletion (P for trend, .03) and with urethritis (odds ratio [OR], 2.4; 95% confidence interval [CI], 1.2-4.6) or gonorrhea (OR, 2.9; 95% CI, 1.5-5.8). Two multivariate models were constructed that included age, CD4 cell count < 200/mm3, and either urethritis or gonococcal infection. Detection of HIV-infected cells in urethral secretions was independently associated with < 200 CD4 cells/mm3 (OR, 2.2; 95% CI, 0.9-5.2; P = .05) and urethritis (OR, 2.7; 95% CI, 1.3-5.3; P = .003) in the first model and with gonococcal infection (OR, 3.2; 95% CI, 1.6-6.4; P < .001) in the second model. Successful treatment of gonococcal urethritis was associated with a 2-fold reduction in urethral HIV DNA (44% vs. 21%; P = .02). Thus, treatment of gonococcal urethritis may be an effective strategy for reducing HIV transmission. | en |
dc.language.iso | en | en |
dc.title | Human immunodeficiency virus DNA in urethral secretions in men: association with gonococcal urethritis and CD4 cell depletion | en |
dc.type | Article | en |
local.publisher | Department of Medicine, University of Washington, Seattle, USA. | en |
local.publisher | Department of Medical Microbiology, University of Nairobi | en |