dc.contributor.author | Duprat, C | |
dc.contributor.author | Mohammed, Z | |
dc.contributor.author | Datta, P | |
dc.contributor.author | Stackiw, W | |
dc.contributor.author | Ndinya-Achola, JO | |
dc.contributor.author | Embree, JE | |
dc.contributor.author | Holmes, KK | |
dc.contributor.author | Plummer, FA | |
dc.date.accessioned | 2013-04-26T08:03:38Z | |
dc.date.available | 2013-04-26T08:03:38Z | |
dc.date.issued | 1994 | |
dc.identifier.citation | Pediatr Infect Dis J. 1994 Jul;13(7):603-8 | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/7970947 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16952 | |
dc.description.abstract | Breast-feeding plays a potentially significant role in mother to child transmission of human immunodeficiency virus type 1 (HIV-1). The additional transmission risk attributable to breast-feeding and the factors that enhance or inhibit transmission are presently unknown. One mechanism by which breast milk might inhibit HIV-1 transmission is the presence of specific antibodies directed against HIV-1 in breast milk of seropositive mothers. In this study serum and breast milk samples from women in Nairobi, Kenya, were tested to determine the prevalence of HIV-1 IgA antibodies. A Western blot test developed in our laboratory was used to detect anti-HIV-1 immunoglobulin A in serum and anti-HIV-1 secretory IgA (sIgA) in breast milk. Ninety-four percent of 63 HIV-1 seropositive women had anti-HIV-1 IgA in serum and 59% had anti-HIV-1 sIgA in their breast milk. No significant associations with maternal characteristics or serum anti-HIV-1 IgA or IgG banding patterns and the presence of anti-HIV-1 sIgA in breast milk were found. No protective effect of anti-HIV-1 sIgA was seen regarding mother to child transmission; however, further studies are necessary to determine the effect of these antibodies in maternal sera or in breast milk on the efficacy of HIV-1 transmission | en |
dc.language.iso | en | en |
dc.title | Human immunodeficiency virus type 1 IgA antibody in breast milk and serum. | en |
dc.type | Article | en |
local.publisher | Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada | en |