dc.contributor.author | Plourde, PJ | |
dc.contributor.author | D'Costa, LJ | |
dc.contributor.author | Agoki, E | |
dc.contributor.author | Ombette, J | |
dc.contributor.author | Ndinya-Achola, JO | |
dc.contributor.author | Slaney, LA | |
dc.contributor.author | Plummer, FA | |
dc.date.accessioned | 2013-04-26T09:39:19Z | |
dc.date.available | 2013-04-26T09:39:19Z | |
dc.date.issued | 1992 | |
dc.identifier.citation | J Infect Dis. 1992 May;165(5):949-52 | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/1569347 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17002 | |
dc.description.abstract | Chancroid is linked to the spread of human immunodeficiency virus type 1 (HIV-1) in East Africa. Effective, easily administered therapy is a priority for the control of Haemophilus ducreyi. The efficacy of a single oral dose of fleroxacin, 400 mg, was compared to a 3-day oral course of trimethoprim-sulfamethoxazole (TMP-SMZ), 160/800 mg, twice daily for the treatment of chancroid in 98 HIV-1-seronegative men in Nairobi, Kenya. No differences were noted between the two groups with respect to demographic characteristics, sexual behavior, and clinical characteristics. Culture-proven failure occurred in 1 (3%) of 36 fleroxacin-treated patients and in 11 (30%) of 37 TMP-SMZ-treated patients (P = .005). Fleroxacin, as a single oral dose, is an effective treatment for culture-proven chancroid in patients who are HIV-1 seronegative. TMP-SMZ is no longer predictably effective due to the recent emergence of resistance to both sulfonamides and to trimethoprim. | en |
dc.language.iso | en | en |
dc.publisher | World Health Organisation Centre for Research and Training on Sexually Transmitted Diseases | en |
dc.title | A randomized, double-blind study of the efficacy of fleroxacin versus trimethoprim-sulfamethoxazole in men with culture-proven chancroid. | en |
dc.type | Article | en |
local.publisher | Department of Medical Microbiology, University of Nairobi, Kenya. | en |