Effect of human immunodeficiency virus (HIV) type 1 viral genotype on mother-to-child transmission of HIV-1.
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Date
2000Author
Murray, MC
Embree, JE
Ramdahin, SG
Anzala Aggrey O.
Njenga, S
Plummer, FA
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The objective of this study was to determine whether the maternal infecting human immunodeficiency virus (HIV) type 1 clade affects mother-to-child transmission frequency. Mothers in the mother-to-child HIV-1 transmission study in Nairobi, Kenya, were grouped by HIV-1 status of their first enrolled child: uninfected, perinatally infected, or postnatally infected. Restriction fragment length polymorphism (RFLP) analysis was used to determine HIV-1 viral clades of nested polymerase chain reaction products from HIV-1 protease or p24 genes. When inconclusive, sequencing determined the clade. Clade distributions within the groups were compared. The 3 groups displayed a uniform clade distribution. The predominant clades were A (59%) and D (20%). Clades B, C, F, mixed, and recombinant infections comprised the remainder (21%). No significant association was seen between clades A and D and either frequency or mode of vertical transmission. RFLP analysis revealed 2 clade B infections, 9 mixed, and 5 p24/protease recombinant infections in the study population.
URI
http://www.ncbi.nlm.nih.gov/pubmed/10669368http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17181
Citation
J Infect Dis. 2000 Feb;181(2):746-9Publisher
Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
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- Faculty of Health Sciences (FHS) [10378]