Chemical studies on the roots of Uvaria welwitschii.

dc.contributor.author	Moriyasu, M,
dc.contributor.author	Nakatani, N
dc.contributor.author	Ichimaru, M
dc.contributor.author	Nishiyama, Y
dc.contributor.author	Kato, A,
dc.contributor.author	Mathenge, S.G
dc.contributor.author	Juma, F.D
dc.contributor.author	Chalo Mutiso, P.B
dc.date.accessioned	2013-04-27T10:47:38Z
dc.date.available	2013-04-27T10:47:38Z
dc.date.issued	2011
dc.identifier.citation	J Nat Med. 2011 Apr;65(2):313-21.	en
dc.identifier.uri	http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/21234693
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17375
dc.description.abstract	A chemical investigation of the chloroform extract of the roots of Uvaria welwitschii (Annonaceae), an African traditional medicine taken for stomach ache, led to the isolation of eight new compounds, named welwitschins A-H (1-8), together with five known compounds (9-13). The structural elucidation by spectroscopic studies of the compounds isolated is described. All new compounds were flavonoids having a 2-hydroxy-3,4,6-trimethoxyphenyl moiety in the A-ring, and unsubstituted phenyl in the B-ring. Four of them (1-4) were monomeric flavonoids while the others (5-8) were dimeric flavonoids. The cytotoxicity of the isolated compounds against human promyelocytic leukemia HL-60 cells was investigated.	en
dc.language.iso	en	en
dc.title	Chemical studies on the roots of Uvaria welwitschii.	en
dc.type	Article	en