Hydroxyespintanol and schefflerichalcone: two new compounds from Uvaria scheffleri.

dc.contributor.author	Ichimaru, M
dc.contributor.author	Nakatani, N,
dc.contributor.author	Moriyasu, M,
dc.contributor.author	Nishiyama, Y,
dc.contributor.author	Kato, A
dc.contributor.author	Mathenge, S.G
dc.contributor.author	Juma, F.D
dc.contributor.author	ChaloMutiso, P.B
dc.date.accessioned	2013-04-27T10:51:45Z
dc.date.available	2013-04-27T10:51:45Z
dc.date.issued	2010
dc.identifier.citation	J Nat Med. 2010 Jan;64(1):75-9	en
dc.identifier.uri	http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/19756918
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17377
dc.description.abstract	A chemical investigation of the petroleum ether extract and chloroform extract of the root of Uvaria scheffleri Diels (Annonaceae) led to the isolation of two new compounds, named hydroxyespintanol (1) and schefflerichalcone (2), together with eight known compounds (3-10). The structural elucidation of compounds 1 and 2 by spectroscopic studies is described. The cytotoxicity of the isolated compounds against human promyelocytic leukemia HL-60 cells was studied. Among these, 2'-hydroxy-3',4',6'-trimethoxychalcone (5) exhibited cytotoxicity (IC(50) 12 microM), and espintanol (3), which was the main ingredient, also showed some cytotoxicity (IC(50) 44 microM)	en
dc.language.iso	en	en
dc.title	Hydroxyespintanol and schefflerichalcone: two new compounds from Uvaria scheffleri.	en
dc.type	Article	en